In HFrEF hearts Contractility
Drives Performance1‑3

There were 900,000 hospital discharges for HF in 20144

See the Patient Burden

Current therapies for HF address compensatory mechanisms, but with unintended effects2,5‑7

Understand the Challenges

Reduced contractility is central to HF5,7

Get to the Heart of the Matter

HF, heart failure; HFrEF, heart failure with reduced ejection fraction.


1. Hartupee J, et al. Nat Rev Cardiol. 2017;14:30‑38. 2. Malik FI, et al. J Mol Cell Cardiol. 2011;51:454‑461. 3. Fearnley CJ, et al. Cold Spring Harb Perspect Biol. 2011;3:a004242. doi:10.1101/cshperspect.a004242. 4. Benjamin EJ, et al. Circulation. 2019;139:e56‑e528. 5. Kemp CD, et al. Cardiovasc Pathol. 2012;21:365‑371. 6. Brown DA, et al. Nat Rev Cardiol. 2017;14:238‑250. 7. Mann DL, et al. Heart failure and cor pulmonale. In: Longo DL, et al, eds. Harrison’s Principles of Internal Medicine. 18th ed. McGraw‑Hill; 2012:1901‑1915.