is at the heart of heart failure with reduced ejection fraction (HFrEF)1

HFrEF is a direct result of weakened contractility, which may ultimately progress to worsening heart failure2

Heart muscle function is dependent on actin and myosin, the key contractile proteins of the sarcomere.3

The role of contractility in cardiac function

Watch this video to see how contractility plays an integral role in HFrEF, and how it might impact your future treatment strategies.

The progression toward worsening heart failure

Even with SOC treatment, patients with chronic HFrEF often experience worsening of function and symptoms. This highlights the continuous need to advance research for new therapeutic interventions.4,5

More than 75% of heart failure hospitalizations are due to worsening heart failure.6

The burden from HFrEF and worsening heart failure is multifaceted and impactful.4

Even with periods of stabilization on treatment with SOC, patients with worsening heart failure may still require additional treatment options.7,8

Novel MOAs have the potential to offer something more than what is expected with current SOC.

Some patients will respond less and less to SOC while the sustained neurohormonal activation drives the progression of HFrEF.7,9

Focusing on contractility may be a promising alternative.
HFrEF, heart failure with reduced ejection fraction; SOC, standard of care.

References: 1. Kemp CD et al. Cardiovasc Pathol. 2012;21:365‑371. 2. Mann DL, et al. Heart failure and cor pulmonale. In: Longo DL, et al, eds. Harrison’s Principles of Internal Medicine. 18th ed. McGraw‑Hill; 2012:1901‑1915. 3. Psotka MA et al. J Am Coll Cardiol. 2019;73:2345-2353. 4. Butler J et al. J Am Coll Cardiol. 2019;73(8):935-944. 5. Fiuzat M et al. JACC. 2022;79(5):504-510. 6. Chang PP et al. Am J Cardiol. 2014;113(3):504-510. 7. Heidenreich PA et al. J Am Coll Cardiol. 2022;79(17):e2-e159. 8. Mallick A et al. J Am Coll Cardiol. 2016;4:749-755. 9. Hartupee et al. Nat Rev Cardiol. 2017;14(1):30-38.